Here's a suggestive itinerary for a 5-night holiday in New York City from the UK:

Day 1: Arrival in New York City

• Fly from the UK to New York City.
• Arrive in New York City and transfer to your hotel.
• Spend the afternoon exploring the vibrant neighborhood of Times Square, with its dazzling lights, Broadway theaters, and iconic billboards.
• Enjoy dinner at a local restaurant and soak in the energetic atmosphere of the city.

Day 2: Exploring Manhattan

• Start your day with a visit to the Statue of Liberty and Ellis Island. Take a ferry ride to Liberty Island and explore the grounds of the Statue of Liberty. Visit the Ellis Island Immigration Museum to learn about the history of immigration to the United States.
• Afterward, head to Lower Manhattan and visit the 9/11 Memorial and Museum to pay tribute to the victims of the September 11 attacks.
• Explore the Financial District and Wall Street, home to the New York Stock Exchange and historic landmarks.
• In the evening, take a stroll along the High Line Park, a unique elevated park built on a historic freight rail line.

Day 3: Midtown Manhattan and Central Park

• Explore Midtown Manhattan, starting with a visit to the iconic Empire State Building. Enjoy panoramic views of the city from the observation deck.
• Visit the famous landmarks of Rockefeller Center and take an elevator to the Top of the Rock for more breathtaking views.
• Explore the world-famous Fifth Avenue and indulge in shopping at luxury boutiques and department stores.
• In the afternoon, visit Central Park and enjoy a leisurely stroll through the park's beautiful landscapes. You can also rent a bike or take a horse-drawn carriage ride.
• In the evening, catch a Broadway show or enjoy dinner at a trendy restaurant.

Day 4: Museums and Cultural Experiences

• Spend the day immersing yourself in the rich cultural scene of New York City.
• Visit the Metropolitan Museum of Art (the Met) and explore its vast collection of art from around the world.
• Explore the Museum of Modern Art (MoMA) and admire works by renowned artists such as Van Gogh, Picasso, and Warhol.
• Visit the American Museum of Natural History and discover its fascinating exhibits on dinosaurs, human evolution, and the universe.
• In the evening, enjoy dinner in Greenwich Village, a vibrant neighborhood known for its trendy restaurants and live music venues.

Day 5: Neighborhood Exploration and Shopping

• Explore diverse neighborhoods such as SoHo, known for its stylish boutiques and art galleries.
• Visit the trendy neighborhood of Williamsburg in Brooklyn and enjoy its lively atmosphere, street art, and hip cafes.
• Take a walk across the iconic Brooklyn Bridge for stunning views of the Manhattan skyline.
• Indulge in some retail therapy at popular shopping destinations like Macy's, Bloomingdale's, or the luxury stores on Fifth Avenue.
• In the evening, experience the vibrant nightlife of New York City in neighborhoods like the Meatpacking District or the Lower East Side.

Day 6: Departure

• Enjoy your final breakfast in New York City.
• Depending on your flight time, you may have some free time for last-minute shopping or sightseeing.
• Transfer to the airport for your return flight to the UK.

Please note that this itinerary provides a general framework for your 5-night holiday in New York City, and you can adjust it based on your interests and the specific attractions you wish to visit. New York City offers a wealth of experiences, from iconic landmarks to world-class museums, diverse neighborhoods, and unforgettable culinary delights.